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ABSTRACTGlucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as game-changers across the cardiovascular–kidney–metabolic (CKM) spectrum: overweight/obesity, type 2 diabetes mellitus…
AbstractUromodulin is a kidney-specific glycoprotein which is uniquely synthesized by the epithelial cells lining the thick ascending limb and early distal convoluted tubule. Among multiple roles in…
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Karagiannidis, AG., Theodorakopoulou, MP., Iatridi, F., Ortiz, A., Sarafidis, P
AbstractThe burden of chronic kidney disease (CKD) and its risk factors are projected to rise in parallel with the rapidly ageing global population. By 2050, the prevalence of CKD category G3–G5 may…
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July 2024
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Chesnaye, NC., Ortiz, A., Zoccali, C., Stel, VS., Jager, KJ.
Despite the availability of kidney replacement therapy (KRT), chronic kidney disease (CKD) is among the fastest increasing global causes of premature death. Longer life expectancy and population aging…
Sex (biologically determined) and gender (socially constructed) modulate manifestations and prognosis of a vast number of diseases, including cardiovascular disease (CVD) and chronic kidney disease…
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February 2024
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Balafa, O., Fernandez-Fernandez, B., Ortiz, A., Dounousi, E., Ekart, R., Ferro, CJ., Mark, PB., Valdivielso, JM., Del Vecchio, L., Mallamaci, F.
SummaryBackgroundGlobally, the burden of chronic kidney disease and ensuing need for kidney replacement therapy (KRT)—dialysis or kidney transplantation—are increasing. Despite the mortality benefit…
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August 2025
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Zambeli-Ljepović, A., Tungsanga, S., Ghimire, A., Bello, ak., Okpechi, IG., Siyoum, MT., Mushi, FA., Asiimwe, F., Bagasha, P., Okungu, V., Bertozzi, SM., Hoffmann, TJ., Thomson, D., Muller, E., Scott, JW., Syed, S., Ascher, N., Stock, P., Rose, J.
Diabetes is the most common cause of chronic kidney disease (CKD), a condition found in 850 million persons and projected to become the fifth global cause of death by 2040. Research is needed that…
A practical, collaborative, open access e‑book designed to help support educators and medical schools in embedding education for sustainable healthcare (ESH) into their medical curricula. As a…
The current kidney care model-focused on late-stage disease and in-center hemodialysis-is unsustainable, because of costs, environmental burden, poor outcomes, and reduced quality of life.The 78th…
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March 2026
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Vanholder, R., Abdellatif, D., Dos Santos Jr, ACS., Correa-Rotter, R., Gopalakrishnan, N., Wang, B., Roumeliotis, S., Balducci, A., Haris, A., Yadla, M., Hsiao, L.
